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Molecular diagnostic assays for use in medical diagnostic and monitoring applications and for drug discovery and development through pharmacodiagnostics; computer programs and algorithms for performing and reporting on assays for the diagnosis of diseases; computer programs and algorithms that identify or assist in the identificaiton of biochemical markers for disease states; computer programs and algorithms for assessing drug efficacy and targets; scientific instruments, namely, spectrometers and related instrumentation, for developing chemical markers for disease states; scientific instruments, namely, spectrometers and related instrumentation, for performing diagnostics for diseases; scientific instruments, namely mass spectrometers and related instrumentation, for assessing drug efficacy and determining targets for drugs; scientific instruments, namely mass spectrometers and related intrumentation, for measuring metabolite levels